Oligonucleotide Analysis Without Derivatization

Technical Article # 4:

Oligonucleotide Analysis Without  Derivativization

We take a look at a novel HILICpak column to improve both modified and unmodified oligonucleotide separations


  • No Ion-Pair Reagents

  • Targeting 60 mer chains and below

  • Simple eluents and conditions for purification

In the literature

Oligonucleotide analysis by hydrophilic interaction liquid chromatography-mass spectrometry in the absence of ion-pair reagents

P.A. Lobue, M. Jora, B. Addepalli, et al., J. Chromatogr. A (2019)


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